Genetics, Cell Biology and Development
Medical School
Twin Cities
Award Year
2026
University Award
McKnight Land-Grant Professorship
Decoding Somatic Genome Mutations in Human Aging
Xiao Dong investigates how mutations that arise in the DNA of our body’s cells over a lifetime may contribute to aging and age-related diseases. His team develops advanced sequencing technologies to measure these hidden mutations one cell at a time, and uses large-scale data to reveal how they disrupt normal gene activity. By identifying what drives mutation buildup and how it impairs cell function, his research seeks new strategies to protect genome health and extend healthy aging.